王永刚

王永刚 主任医师，教授，博生导师，头痛科主任

2007年 博士毕业 于 第二军医大学

2007年-2013年 上海市第十人民医院 神经内科  住院/主治/副主任医师 副教授 硕士生导师

2013年-2019年 上海交通大学医学院附属仁济医院  神经内科   副主任医师 副教授 硕士生导师/ 主任医师 教授 博士生导师

2019年-至今      首都医科大学附属北京天坛医院 神经病学中心 头痛科 科主任   主任医师/教授 /博士生导师

擅长各种原发性头痛（偏头痛，紧张型头痛，丛集性头痛）、复杂头痛（药物过度使用头痛，新发每日持续性头痛）、青少年头痛以及继发性头痛的诊断与治疗；以及头痛及其他神经系统疾病合并的头晕，情绪和睡眠障碍等疾病的药物综合治疗。

研究方向： 1. 原发性头痛的诊疗与临床研究  2. 原发性头痛的神经生物学机制探讨  3. 神经损伤与修复的机制研究  4. 头痛相关的睡眠障碍，情感障碍等共患病的临床诊疗。

发表论文：

1. Fine-mapping of ZDHHC2 identifies risk variants for schizophrenia in the Han Chinese population. Zhang, H., Li, X., Ma, C., Wang, K., Zhou, J., Chen, J., Wang, Y., & Shi, Y. Mol Genet Genomic Med. 2020 Mar 17:e1190.  IF=1.995

2. Lower Vitamin D Levels in Panic attacks in Shanghai: A Case-Control Study. Asian Journal of Psychiatry. Liu C, Jiang W, Deng M, Wang F, Wang Y. Asian J Psychiatr. 2020 Feb 18 51:101948.  IF=2.529

3. SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control study. Jian X, Chen J, Li Z, Song Z, Zhou J, Xu W, Liu Y, Shen J, Wang Y, Yi Q, Shi Y. BMC Psychiatry. 2019 Sep 18;19(1):293. IF=2.666

4. Predictors of relapse in patients with medication overuse headache in Shanghai: A retrospective study with a 6-month follow-up. Xin Yuan, Weiqing Jiang, Xiao Ren, Chen Liu, Yuanmei Pan, Jing Zou, Xianguo Jiang, Weihua Ji, Ying Li, Zhiying Feng, Lingling Yao, Yonggang Wang, J Clin Neurosci. 2019 Dec;70:33-36. IF=1.593

5. Association of fat mass and obesity-associated and retinitis pigmentosa guanosine triphosphatase (GTPase) regulator-interacting protein-1 like polymorphisms with body mass index in Chinese women. Chen B, Li Z, Chen J, Ji J, Shen J, Xu Y, Zhao Y, Liu D, Shen Y, Zhang W, Shen J, Wang Y, Shi Y. Endocr J. 2018 Jul 28;65(7):783-791. IF=1.911

6. Association study of NDST3 gene for schizophrenia, bipolar disorder, major depressive disorder in the Han Chinese population. Wang L, Chen J,  Li, Z, Sun W, Chen B, Li S, Li W, Lu D, Wang Y, Shi Y. AM J MED GENET B, 2018 Jan;177(1):3-9. IF=3.016

7. SNAP25 is associated with schizophrenia and major depressive disorder in the Han Chinese population. Wang Q, Wang Y, Ji W, Zhou G, He K, Li Z, Chen J, Li W, Wen Z, Shen J, Qiang Y, Ji J, Wang Y, Shi Y, Yi Q, Wang Y. J Clin Psychiatry. 2015 Jan;76(1):e76-82. doi: 10.4088/JCP.13m08962. IF=5.498

8. The GluN2B subunit of N-methy-D-asparate receptor regulates the radial migration of cortical neurons in vivo. Jiang H, Jiang W, Zou J, Wang B, Yu M, Pan Y, Lin Y, Mao Y, Wang Y. Brain Res. 2015 Jun 12;1610(3):20-32. IF=2.561

9. Common Variants in the CDH7 Gene are Associated with Major Depressive Disorder in the Han Chinese Population. Xingwang Li, Qingzhong Wang, Kuanjun He, Zhiqiang Li, Jianhua Chen, Wenjin Li, Zujia Wen, Jiawei Shen, Yu Qiang, Jue Ji, Guoyin Feng, Guang He, He Lin, Yonggang Wang, Yongyong Shi.　Behav Genet 2014 44(2):97–101 IF=2.839

10. L-3-n-butylphthalide protects rats’ cardiomyocytes from ischaemia/reperfusion-induced apoptosis by affecting the mitochondrial apoptosis pathway. Yonggang Wang, Yi Li,  C.-Y. Wang,  J.-W. Ai,  X.-Y. Dong,  H.-Y. Huang,  Z.-Y. Feng, Y.-M. Pan,  Y. Lin,  B.-X. Wang  and L.-L. Yao. Acta Physiologica 2014 Mar;210(3):524-33 IF=2.496

11. Expression and ultrastructural localization of Mint2 in the spinal cord of rats. Yao LL, Liu XY, Jin JY, Tao BB, Chen YJ, Yu YC, Bian WH, Yu J, Huang J, Wang YG. Molecular Biology Reports 2011 ;38(1):667-73 IF=2.929

12. Hydrogen sulfide protects cardiomyocytes from hypoxia/ reoxygenationinduced apoptosis by preventing GSK-3β-dependent opening of mPTP. Yao LL, Huang XW, Wang YG, Cao YX, Zhang CC, Zhu YC. Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1310-9 IF=3.881

13. Survivin is involved in the anti-apoptotic effect of edaravone in PC12 cells. Xue-Yuan Liu, Ling-Ling Yao, Yu-Juan Chen, Bei-Bei Tao, Yong-Chun Yu, Wei-Hong Bian, Jing Yu and Yong-Gang Wang. Mol Cell Biochem. 2009 Jul;327(1-2):21-8. IF=1.896

14. Interaction of mint2 with TRKA is involved in regulation of nerve growth factor-induced neurite outgrowth. Yong Zhang,‡ , Yong-Gang Wang‡, Qi Zhang, Xiu-Jie Liu, Xuan Liu, Li Jiao, Wei Zhu, Zhao-Huan Zhang, Xiao-Lin Zhao and Cheng He. J.Biol.Chem.2009 May 1;284(18):12469-79. IF=1.896

15. Nogo-A inhibits necdin-accelerated neurite outgrowth by retaining necdin in the cytoplasm. Xiujie Liu‡, Yonggang Wang‡, Yong Zhang, Wei Zhu, Xiaohui Xu, Michio Niinobe, Kazuaki Yoshikawa, Changlin Lu, Cheng He. Molecular and Cellular Neuroscience  2009 May;41(1):51-61. IF=3.596

16. Ling-Ling Yao,*, Yong-Gang Wang,*, Wen-Jie Cai, Tai Yao and Yi-Chun Zhu, Survivin mediates the anti-apoptotic effect of δ-opioid receptor stimulation in cardiomyocytes. Journal of Cell Science 2007, 120(5), 895-907. IF=6.383

17. Ling-Ling Yao1,*, Yong-Gang Wang2, Xiu-Jie Liu3, Yu Zhou1, Na Li1, Jun Liu1, Yi-Chun Zhu1 Phenylephrine protects cardiomyocytes from starvation-induced apoptosis by increasing glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity Journal of Cellular Physiology  published online: 21 JUN 2012 DOI: 10.1002/jcp.24053. IF=4.218

18. Yong Zhang*, Wei Zhu*, Yong-Gang Wang, Xiu-Jie Liu, Li Jiao, Xuan Liu, Zhao-Huan Zhang, Chang-Lin Lu and Cheng He‡ Interaction of SH2-Bβ with RET is involved insignaling of GDNF-induced neurite outgrowth. Journal of Cell Science 2006, 119(8), 1666-1676 IF=6.427

国家自然科学基金项目：

1. 项目编号：91849104，国家自然科学基金委重大研究计划培育项目，《RBM8a介导Wnt信号调节神经元再生在衰老过程中的作用及机制研究》50万元 2019.01 - 2021.12

2. 项目编号：31770800，国家自然科学基金委面上项目资助，《内源性硫化氢影响斑马鱼脑血管发育的机制研究》55万元 2018.01-2021.12

3. 项目编号：20161414，上海市教委——高峰临床医学“研究型医师”,《重症肌无力及相关神经免疫疾病抗体检测技术临床应用与推广》100万元，2016.07-2019.06

4. 项目编号：81571329，国家自然科学基金委面上项目资助，《汉族人群重症抑郁症候选基因筛查、分子网络分析及其功能验证》68.4万元  2016.01-2019.12

5. 项目编号：31240001，国家自然科学基金委专项基金资助， 《Trpc3/6介导Neuregulin-1引起的钙内流参与外周雪旺细胞髓鞘化》 15万元， 2012.06—2013.05；

6. 项目编号：31271140，国家自然科学基金委面上项目资助，《神经干细胞巢内小胶质细胞对Wnt/β-catenin通路的调节机制及其在多发性硬化发病中的机制研究》 80万元， 2013.01—2016.12；